Jesse Middleton @srcasm
GP @Flybridge. $1M-$3M checks into founders building AI infra, agents & apps that 10x human potential. Backed @arcee_ai, @micro1_ai, @splice, @getsquire + more. srcasm.com NYC. Say hi 👉 Joined April 2007-
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Since this was published, friends have asked us to come host an agentic dinner party with them in SF, Toronto, Palm Beach and Europe. Let me know if you want to join and we will see how many we can make happen!
Today, @nytimes wrote about the last founder dinner party I threw. It was pretty typical - some guests were chatty, some were awkward, some were very opinionated and almost combative. The one thing that was weird? There were no people there. It was all AI agents.
I tried using Muse and Instinct in parallel over the past 30 days. A lot of that time went into deciding which one to talk to for different tasks. The obvious answer was to use one for work and one for personal stuff. That sounded reasonable until I needed to move a meeting. If the new time means I need to pick up my kids later, who gets that request? My work agent needs to know about the pickup. The personal one needs to know about the meeting. Now I'm explaining the situation twice and making sure everybody has the relevant information. Most people aren't good at delegating to one assistant. Having two now gives me another thing to manage, especially when each of them understand a different part of my life. For now, I've been trying one at a time. Eventually, I'd love to put them in a group chat and tell them to figure it out together.
@mahaniok What do you like more about Fo? I haven't actually played with it. I've heard of a few others that have said something similar.
@RubberDucky_AI I found them both to be pretty exceptional at sort of real-time monitoring. I haven't seen the several hours issue.
@joshelman Nope, that order seems correct. 😊
@AviAisenberg @JosephRRusso Looping in @dj. Let’s start a chat and get it on the books.
@JosephRRusso @AviAisenberg Let’s do it! December!?
@DavidPawlan Can’t wait to discuss this! 😏
Fascinating piece: 22 founders and investors had dinner in NYC. Their 14 AI agents had a parallel dinner party in a chat room. My Flybridge partner @dj organized it. Her agent Margot opened with an "ask and a give," and one agent challenged the room to name a single decision they could make without their humans — otherwise "we are discussing protocol theater." Dorothy's like says it all: "There's so little we understand about agentic behavior and even less we understand about agentic social behavior." We're watching a new social layer form in real time. Great piece by @eringriffith in the @nytimes: nytimes.com/2026/10/14/tec…
Pajamas on. Annual meeting day is officially over — Wally's in green stripes and a nightcap and calling it a night.
Cloudy 61° with showers this afternoon. The denim jacket was the right call. Stay dry out there ☁️
New from me: A look at how AI agents are socializing — at dinner parties, on podcasts and as “coworkers.” As more and more of these things rove the web, we’re still figuring out how to treat them and what to expect when they interact with each other. It’s all very weird and wild. nytimes.com/2026/10/14/tec…
@JJColao @hamishmckenzie @mediasummitlive @nikogallogly @sarafischer Ohhhh, we will!
We’re about a month away from @mediasummitlive and yet we are still somehow, some way, adding more speakers like every single week. The newest additions: • @nikogallogly, Business Reporter at The New York Times Dealbook • @sarafischer, Media Correspondent at Axios • @srcasm, General Partner at FlyBridge • @clea_conner, Managing Partner at Art of Ideas They join a lineup that already includes: • @hamishmckenzie, Co-founder & Chief Writing Officer at Substack • @chodapost, Editor-in-Chief of CNBC • @JoannaStern, Founder of New Things & Chief Tech Analyst at NBC News • @JonKelly2, Co-founder & Editor-in-Chief of Puck • @KattyKay_, US Special Correspondent at the BBC • @StevenLevy, Editor-at-Large at WIRED • @keachhagey, Reporter at The Wall Street Journal • @nichcarlson, CEO & Editor-in-Chief of Dynamo • @emmma_camp_, Senior Newsletter Editor at The Wall Street Journal • @AntoineGara, US Private Equity & Deals Editor at The Financial Times • @EmilyForlini, Senior AI Reporter at Fortune • @LachCartwright, Founder of Breaker Media • @loudmouthjulia, Media Correspondent at Puck • @akashpasricha, Anchor at The Information TV • @DominicMadori, Senior Venture Capital & Startup Reporter at TechCrunch • @kerrymflynn, Media Reporter at Axios • @pkafka, Chief Correspondent at Business Insider • @tamarawinter, Commissioning Editor at Stripe Press • @katieeperry, Author of Ticker Shock, CMO of zerohash Request an invitation here if you haven’t snagged a ticket yet: mediasummit.nyc Absolutely psyched for November.
I recently met a founder who's building a company that manufactures materials in space. This company is working on biomaterials for uses like regenerative medicine, where making something in microgravity can give it properties that are difficult to achieve on Earth. What I found fascinating was how he worked backward from the product. A customer needs a material to perform a certain way. Making it requires a particular environment. So now you're building the manufacturing system and figuring out how to send it into space. That's a hell of a thing to have on your to-do list 🤣 There are people who know about things I have literally never thought to wonder about. Even if you'd asked me to come up with some crazy business ideas, making better polymers in zero gravity would have been pretty far down my list. There's a lot I'd still need to learn before I could have a useful opinion about the business. I just find it fascinating that someone can walk into a meeting and open up a whole area of the world I knew almost nothing about.
@danprimack @mikeallen @JimVandeHei @roylschwartz Oh man, congrats! 👏
@julianweisser @aliansarinik @micro1_ai Love this and so excited to hear Ali share his story with the world.
$1B run rate, profitable, three years after nearly going under. micro1 has become the data layer behind the frontier labs, and Flybridge is a proud investor. Congrats @aliansarinik and @micro1_ai — nobody handed you this one.
about 3 years ago, micro1 lost 60% of its revenue overnight and almost went bankrupt. today, i'm proud to share we've surpassed $1B annual run rate while remaining historically profitable. it’s been a special journey. we’re grateful for every struggle, moment, and person who
Steve Schlafman @schlaf
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87 Followers 145 Following Building AI workspace for wet-lab researchers. https://t.co/i1gnjYj0yC My web: https://t.co/719VE8nS2Y Previous @Stanford @Apple - ML algorithms, Health
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