ShorterLab @ShorterLab
Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn med.upenn.edu/shorterlab/ind… University of Pennsylvania Joined January 2012-
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Disassembly of mitochondrial cristae architecture drives neurodegeneration in Huntington’s disease: link.springer.com/article/10.118…
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Memory stays strong in old age when this brain enzyme is active nature.com/articles/d4158…
An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience: nature.com/articles/s4159…
Beyond the obvious pocket: nature.com/articles/s4158…
Tryptoline stereoprobe elaboration identifies inhibitors of the GRPEL1–HSPA9 complex: nature.com/articles/s4158…
Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging: nature.com/articles/s4358…
Integration-Associated Paraspinal Neoplasm after AAV Gene Therapy: nejm.org/doi/full/10.10…
A B1 SINE element within the mouse Malat1 long noncoding RNA acts as an internal ribosome entry site mediating micropeptide translation: science.org/doi/10.1126/sc…
De novo MAP2K4 variants cause a neurodevelopmental syndrome and impaired JNK signaling in iPSC-derived neurons: cell.com/ajhg/fulltext/…
Programming biological behavior with AI-guided de novo protein design: cell.com/molecular-cell…
Functional diversification of the cephalopod proteome by RNA editing: cell.com/cell/fulltext/…
Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer’s disease: science.org/doi/10.1126/sc…
P-body-mediated RNA decay controls neural crest EMT: pnas.org/doi/10.1073/pn…
A second-generation “hypoxia in a pill” rescues neurodegenerative phenotypes across distinct mouse models: pnas.org/doi/10.1073/pn…
On the Polymorph-Selection Determinants of α-Synuclein Amyloid Fibrils Studied at Atomic Resolution: elifesciences.org/reviewed-prepr…
Uncovering essential RNA components of fusion oncoprotein condensates using bicon-seq: link.springer.com/article/10.103…
Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis: science.org/doi/10.1126/sc…
Tau phosphorylation from neuronal adaptation to Alzheimer’s disease: cell.com/neuron/fulltex…
Progressive remodeling of global protein interaction networks in a mouse model of tauopathy: cell.com/cell-reports/f…
PTPRS mediates invasion of tetanus neurotoxin into the central nervous system: cell.com/cell/fulltext/…
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