Tim Draper @TimDraper

Fifteen years. That was the timeline my nuclear physicist friend gave me for a new nuclear plant in the US. Five to design, five for approval, five to build. Most entrepreneurs would have given up right there. @JakeDeWitte doubled down. That is what I invested in. Not the reactor, the founder who hears fifteen years and starts anyway. Now @Oklo is the first nuclear company approved in the US in 40 years, and the future keeps arriving faster than expected.

Draper University @draper_u

a week ago

When Sci-Fi Becomes Reality: Oklo. What if nuclear power plants could be smaller, easier to deploy, and eventually turn used nuclear fuel into a new source of energy? That was the kind of idea @jacobdewitte brought to @TimDraper. When Jake was building @oklo, the timeline alone

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Immusoft to Present Data Highlighting Positive Results from the World’s First Engineered B Cell in a Human Clinical Trial at ASGCT 2026: biospace.com/press-releases…

@Immusoft just presented clinical data at ASGCT on ISP-001 (the world's first engineered B cell therapy ever tested in a human being). They take a patient's own B cells, reprogram them, and put them back in the body. Those cells become miniature factories that continuously produce the enzyme MPS I patients are missing. This means that there’s no more need for twice-weekly infusions and no more spike-and-crash enzyme levels. Your own cells are doing the work indefinitely. The disease they're targeting, Hurler Syndrome, kills most patients within 10 years of diagnosis. There is no cure and the current standard of care is either frequent infusions (forever) or a stem cell transplant that carries its own mortality risk. The clinical data showed: → Favorable safety and tolerability → Measurable biochemical activity → Patients were safely re-dosed They're now planning to expand into pediatric populations with CIRM backing the trial with up to $23M. The FDA has granted Orphan Drug, Rare Pediatric Disease, and Fast Track designations. The implications go way beyond MPS I with every disease that needs sustained protein delivery suddenly having a new option on the table. Exciting times in bio.

@AdamDraper

My son brings out the best in me. We went deep on a variety of topics. Great fun. vimeo.com/1229335995/3d0…

We backed @mogul__club early. After hearing Alex Blackwood’s update at our summit in May, I knew we had to lead the Series A. Alex Blackwood and Joey Gumataotao have a bold vision for real estate investing and the execution to back it up. A true “rhino” in the industry. Congratulations to Alex, Joey, and the entire Mogul team. Proud to keep backing you!

@VikkrammC wrote this fascinating horoscope biography on me. Very thorough, comprehensive and very accurate. Special thanks to Vikkramm for all the extensive research on my history and my horoscope. businessworld.in/article/tim-dr…

In the last decade, we’ve had the honor of partnering with outstanding founders who build great value from nothing. It’s been a privilege to see you all build and grow, for example: → @iceye_global to enable all-weather, day-and-night imaging anywhere on the planet. → @XanaduAI to revolutionize computing through photonic quantum technology. → @Polymarket to harness the power of free markets to demystify real-world events. → @colossal to develop advanced gene editing technology for de-extinction → @arkham to create a central hub for blockchain research, risk management, and market transparency. → @ConsensusNLP to equip users to receive evidence-based answers from over 200 million peer-reviewed papers. → @aureliuslasers to protect citizens from Unmanned Aircraft Systems (UAS) drones at scale. → @FirehawkAero to advance hybrid rocket engines for the future of aerospace. → @rise_pay to enable businesses to easily hire, onboard, and pay global teams across 190+ countries → @VenusAerospace to revolutionize rocket engine propulsion. And truly hundreds of others! Entrepreneurs and founders are superheroes and we’re so lucky to be able to help them on the journey. We started this firm 40 years ago, and every decade gets even more exciting. It’s already been an adventure and we’re truly just getting started! 🚀

Talent is uniformly distributed in society. Opportunities are not. America's Startup is one way we're doing our part about it. A warm welcome to the new @America250 Investor Council members: @CathieDWood, @PratherARK, @christine_tsai, @skg_accel, @billreichert, @SungerBiggs, @BiedermanRob, @Robert_Katz and others. We're all inspired by @RosieRios's original vision: support our nation's youth and democratize entrepreneurship in America. I judged round one... those teams weren't waiting for permission to build. They were already building. Round two: over $1M in cash and prizes, up to $50K non-dilutive per team, finale in DC this December. Undergrad founders: applications close Thursday, Oct 8, 7:59pm EDT. Link in first reply. We're here to help founders fulfill their entrepreneurial dreams. Your part is to apply :)

Something startups often struggle with is biz dev, with a major blocker being hiring and training sales staff fast enough to get revenue in the door. Now imagine anyone starting had a playbook of what everyone on the team knows - and the ability to practice on “live” sales calls with buyer personas and get immediate feedback from a coach. Plus the ability for an AI avatar to answer customer questions when they’re browsing in different time zones. It's AI automation with the sales process… without replacing the humans that close deals. And now @Zoom backs it, too. Really couldn't be prouder of portco Avarra today!! ca.finance.yahoo.com/news/avarra-ra…

We backed @projectsolo early because they're solving the biggest problem of the AI era: knowing who's real. Great to see them shipping.

Solo @projectsolo

a week ago

This AI agent joined 30+ Discord servers overnight and sent 500+ messages. Live counter next to its name: “Humans who noticed: 0” All it was told: get past every CAPTCHA and accept all the terms. It did. No custom exploit, just browsing and clicking. CAPTCHA still guards most

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When @BenLamm walked in saying he was going to bring back the woolly mammoth, he immediately had my attention. Now there are dire wolves on the ground and the dodo is on the list. Do not ask whether the pitch sounds crazy. Ask whether the founder can make it happen. Ben could.

Draper University @draper_u

2 weeks ago

When Sci-Fi Becomes Reality: Colossal. “We’re going to bring back the woolly mammoth.” That was the kind of pitch that got @TimDraper’s attention. When @BenLamm started @colossal, de-extinction still sounded much closer to science fiction than venture capital. But the ambition

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A self-driving car I was testing once swerved into oncoming traffic. That was the moment I decided to invest. The full story is in my live conversation with the TBOY podcast in San Francisco, along with why I kept betting on SpaceX after three rockets blew up, the condition I put on Robinhood's founders before writing the first check, and my advice for building the next billion-dollar business. Thanks to @NickOfNewYork and @Jackkramer for having me on. Listen here: podcasts.apple.com/us/podcast/the…

For 250 years, America's story has been driven by people who took a risk on their own ideas. That's what entrepreneurship is: freedom and trust in action. As a member of the Investor Council for America's Startup (@America250) I want to see that same spirit from the next generation. If you're an undergraduate student (or equivalent) at an accredited university, college, or trade school with an idea you're ready to build, this is your moment. Compete for a share of more than $1 million in cash and prizes, and get your idea in front of me and other leading names in tech and business. 1️⃣ Visit the America's Startup website at america250.org/americas-start… 2️⃣ Review the contest rules and confirm your eligibility 3️⃣ Grab your co-founder and submit your application by October 8

Dad’s @nytimes obituary. He also scored a touchdown for dear old Yale, and created the Human Development Index for @UNDP which didn’t make it in. nytimes.com/2026/09/30/tec…

Kairos Health, a former @America250 America's Startup competitor, just got into @ycombinator's Fall 2026 cohort. They built an AI front desk for dental clinics and are now well on their way to scaling. Their story could be yours. If you're an undergrad with a big idea, apply by Oct 8 👇 america250.org/americas-start…

"How did you KNOW Tesla would succeed?" I didn't. But I did the math. And the numbers said: If this works, it's going to work REALLY big. That's the calculation most VCs refuse to make. They want certainty. They want "safe bets." But the safe ones aren't as safe as you think. And the risky ones aren't as risky as you think. The difference is that the “risky” ones have 100x potential. The safe ones have 3x potential. When you actually do the math, the odds of success are about the same. So I'll take the weird founder with the crazy idea over the polished founder with the "proven model" any day. One of them might change the world. The other one is among other “start” copycats.

AI agents have created a new kind of business risk that almost nobody is covering yet: agents accumulate memory. Context, history, judgment built up over months of use. Lose that in an outage and you're not restarting an app but you're re-training a colleague almost from zero. So it's great to see our portfolio company @ArpioRPO getting ahead of it. They just launched automated disaster recovery for agentic AI workloads on @amazon Bedrock, and the key piece is state recovery: the agent comes back with its memory, not as a blank slate. Full recovery in about an hour, where the average ransomware recovery drags on for three weeks. The timing is right. @KPMG_US found that over half of large US companies are already running AI agents. Quietly, these systems have become critical infrastructure, and critical infrastructure deserves protection you can verify. Exactly what drew us to Arpio when we joined their $15M Series A at @DraperVC earlier this year: Doug Neumann and Shaw Terwilliger built recovery for the cloud era while everyone else was retrofitting the tape-backup era. Being first to protect AI agents is what that looks like in practice :) Announcement links in first reply.

What if treating mental health didn’t mean taking a pill every day for the rest of your life? We invested in Eywa Biotech because they are building for a different future. Moving mental healthcare from chronic daily medication toward medicines that can create meaningful, lasting change with one or a few treatments. Now they are taking orders for their first GMP psilocybin capsules in 25mg, 5mg and placebo. They are being produced for clinical trials and research, and for regulated and emerging markets including Australia, the Czech Republic and Switzerland. Researchers, clinics and pharmaceutical companies interested in working with Eywa can reach [email protected] or [email protected]. And they’re not stopping there. Victoria Costa Paz and her team are using synthetic biology to make these medicines more accessible and scalable.

Sabeer and Jack pushed back hard when I suggested putting a message at the bottom of every email. They thought it would cheapen the product. Then they tried it, and Hotmail spread across the planet without a dollar of advertising. This lesson has stuck with me for 30 years: the founders had built the distribution into the product without knowing it. Every email sent was an invitation. When an idea sounds too simple to work, it deserves a second look.

Draper University @draper_u

3 weeks ago

BEFORE IT WAS OBVIOUS: HOTMAIL. Distribution can be the breakthrough. Hotmail did not originally walk into Draper Fisher Jurvetson as Hotmail. Sabeer Bhatia and Jack Smith initially came in with an idea for a web-building tool. As they were leaving, they mentioned another

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